3D Spheroid

/3D Spheroid
3D Spheroid 2017-11-09T12:46:54+00:00

Although two-dimensional (2D) cell cultures have long been the standard for drug development and tumor research, 3D spheroids or tumor cell aggregates more accurately resemble characteristics of tumors growing in vivo. 

3D spheroids are an improved model for representing the intricate cell-cell and cell matrix interactions, and complex transport dynamics for nutrients and cells. 3D spheroids are superior to 2D cell cultures in testing gene expression for drug toxicology screening since they more closely resemble gene expression in vivo.   3D Spheroids have greater stability and a longer lifespan than 2D cell cultures, thus making them an improved predictor of in vivo drug efficacy and toxicity

Journal Articles

JuLI™ Stage, 3D spheroid

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Dose enhancement and cytotoxicity of gold nanoparticles in colon cancer cells when irradiated with kilo- and mega-voltage radiation. (2016)

By Herman Hau, Dipesh Khanal, Linda Rogers, Natalka Suchowerska, Rajiv Kumar, Srinivas Sridhar, David McKenzie and Wojciech Chrzanowski
Bioengineering & translational medicine

JuLI™ Stage, 3D spheroid

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Real-time monitoring of cisplatin cytotoxicity on 3D-spheroid tumor cells. (2016)

By NamHuk Baek, Ok Won Seo, Jaehwa Lee, John Hulme, Seong Soo A. An Drug Design, Development and Therapy

JuLI™ Stage, 3D spheroid

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Monitoring the effects of doxorubicin on 3D-spheroid tumor cells in real-time. (2016)

By NamHuk Baek, Ok Won Seo, MinSung Kim, John Hulme, Seong Soo A An OncoTargets and Therapy

JuLI™ Br, 3D spheroid

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A liver-on-a-chip platform with bioprinted hepatic spheroids. (2016)

By Nupura S Bhise, Vijayan Manoharan, Solange Massa, Ali Tamayol, Masoumeh Ghaderi, Mario Miscuglio, Qi Lang, Yu Shrike Zhang, Su Ryon Shin, Giovanni Calzone, Nasim Annabi, Thomas D Shupe, Colin E Bishop, Anthony Atala, Mehmet R Dokmeci and Ali Khademhosseini
Biofabrication

JuLI™ Br, 3D Speroid

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Curcumin improves the efficacy of cisplatin by targeting cancer stem-like cells through p21 and cyclin D1-mediated tumour cell inhibition in non-small cell lung cancer cell lines. (2015)

By Puteri Baharuddin, Nazilah Satar, Kamal Shaik Fakiruddin, Norashikin Zakaria, Moon Nian Lim, Narazah Mohd Yusoff, Zubaidah Zakaria, Badrul Hisham Yahay
Oncology Reports

JuLI™, 3D speroid

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Thymosin beta 4 gene silencing decreases stemness and invasiveness in glioblastoma. (2013)

By Hans-Georg Wirsching
Brain A Journal of Neurology