Apoptosis

/Apoptosis
Apoptosis 2017-11-09T12:49:43+00:00

Apoptosis, a genetically directed process of programmed cell death, is required for the regulation of physiological functions and the maintenance of tissue homeostasis. During the process, caspases (cysteinyl aspartate proteinases) break down essential cellular components needed for survival and stimulate production of DNases, destroying DNA in the nucleus of the cell. As the cell begins to shrink, macrophages remove the shrinking cell and its components, thus preventing damage to other cells. Abnormal apoptosis is involved in a variety of human diseases including neurodegeneration, autoimmune disorders, and many types of cancer. Understanding the processes and learning how to modulate apoptosis may be used in treating these conditions.

Journal Articles

JuLI™ Stage, Apoptosis

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Identification and validation of compounds selectively killing resistant cancer: delineating cell line specific effects from P-glycoprotein-induced toxicity. (2016)

By András Füredi, Szilárd Tóth, Kornélia Szebényi, Veronika F.S. Pape, Dóra Türk, Nóra Kucsma, László Cervenák, József Tóvári and Gergely Szakács Mol Cancer Ther

JuLI™ Br, Cell viability

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The multi-target drug BAI induces apoptosis in various human cancer cells through modulation of Bcl-xL protein. (2016)

By Shin Kim, Dong Eun Kim, Taeg Kyu Kwon, Jinho Lee, Jong-Wook Park Int J Oncol

JuLI™ Br, Cell proliferation

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Isopolycerasoidol and (6E,10E) Isopolycerasoidol Methyl Ester, Prenylated Benzopyran Derivatives from Pseuduvaria monticola Induce Mitochondrial-Mediated Apoptosis in Human Breast Adenocarcinoma Cells. (2015)

By HairinTaha, Chung Yeng Looi, Aditya Arya, Won Fen Wong, LeeFahYap, Mohadeseh Hasanpourghadi, Mustafa A. Mohd, Ian C. Paterson, Hapipah Mohd Ali PLOS ONE

JuLI™, ROS generation (DCF-DA)

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δ-Tocopherol prevents methylglyoxal-induced apoptosis by reducing ROS generation and inhibiting apoptotic signaling cascades in human umbilical vein endothelial cells. (2015)

By Moon ho Do, Su nam Kim, Seung-Yong Seo, Eui-Ju Yeoc and Sun Yeou Kim
Food & Function

JuLI™ Br, Cell viability

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BAI, a novel Cdk inhibitor, enhances farnesyltransferase inhibitor LB42708-mediated apoptosis in renal carcinoma cells through the downregulation of Bcl-2 and c-FLIP (L). (2014)

By Ji Hoon Jang Yoon Chul Cho Ki Ho Kim Kyung Seop Lee Jinho Lee Dong Eun Kim Jun-Soo Park Byeong-Churl Jang Shin Kim Taeg Kyu Kwon Jong-Wook Park, Taeg Kyu Kwon, Jong-Wook Park
International Journal of Oncology